在美国六个州怀孕期间患有梅毒的妇女的分娩结果,2018-2021年
Jeffrey M Carlson1, Christina L Sancken, Khue Nguyen
1Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, and the Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, and the Georgia Department of Public Health, Atlanta, Georgia; the G2S Corporation, Shavano Park, Texas; the Maricopa County Department of Public Health, Phoenix, Arizona; Chickasaw Nation Industries, Norman, Oklahoma; the New Jersey Department of Health, Trenton, New Jersey; the Washington State Department of Health, Tumwater, Washington; and the New York State Department of Health, Albany, New York.
在怀孕期间适当治疗梅毒可以显著减少死亡出生和低出生体重等不良结果. 未经治疗或治疗不当的梅毒会给母亲和婴儿带来严重的风险.
科学领域:
- 孕产妇和胎儿的医学
- 传染病流行病学 传染病流行病学
- 公共卫生监督是对公共卫生的监督.
背景情况:
- 怀孕期间的梅毒感染对怀孕和新生儿的不良后果构成重大风险.
- 有效的治疗对于减轻这些风险至关重要,但查和治疗方面的差距仍然存在.
研究的目的:
- 检查怀孕期间梅毒治疗状态与母亲和新生儿不良结果之间的关联.
- 量化与孕妇梅毒治疗不充分或没有治疗相关的风险.
主要方法:
- 在2018-2021年对母亲和婴儿的新兴威胁监测网络 (SET-NET) 中利用了来自六个司法管辖区的数据.
- 根据2021年指南将梅毒治疗状态分类为不充分,充分或没有治疗.
- 使用调整后风险比率 (ARRs) 来比较治疗组之间的不良结果,控制关键的人口和临床因素.
主要成果:
- 超过一半 (57.6%) 的1682个怀孕因梅毒而复杂的接受了适当的治疗.
- 没有或不充分治疗的孕妇经历了较高的死产,早产,低出生体重 (LBW) 和新生儿重症监护室 (NICU) 住院的频率.
- 与适当的治疗相比,没有治疗与死亡出生 (3.72),LBW (1.51) 和NICU入院 (1.60) 的aRRs显著增加.
结论:
- 怀孕期间不充分或未经治疗的梅毒与不良结果密切相关,这强调了对及时和有效治疗的关键需求.
- 改善产前查和确保足够的梅毒治疗的系统策略对于减少不良妊娠和新生儿并发症至关重要.
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