对阿片类药物使用障碍和慢性疼痛患者的认知偏差修改没有预测临床结果的变化
Noah R Wolkowicz1,2, Brian Pittman2, Shannon W Schrader1,2
1VA Connecticut Healthcare System, West Haven, CT, USA.
Journal of studies on alcohol and drugs
|June 19, 2025
概括
认知偏差修改 (CBM) 没有改变注意偏差 (AB),也没有改善阿片类药物使用障碍的退伍军人的阿片类药物渴望和疼痛严重程度. 这项试点研究表明,修改AB与临床结果之间存在分歧.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 临床研究 临床研究
背景情况:
- 据假设,注意偏差 (AB) 将物质使用障碍和慢性疼痛联系起来.
- 认知偏差修改 (CBM) 显示了改变ABs的潜力.
- 关于CBM诱导的AB变化是否预测临床症状改善的证据有限.
研究的目的:
- 调查CBM针对阿片类药物和疼痛线索是否会改变阿片类药物使用障碍和中度疼痛的退伍军人中的AB.
- 确定AB的变化是否与疼痛严重程度,干扰,灾难化,阿片类药物渴望和戒断的改善相关.
主要方法:
- 一项为期4周的临床试验的二次分析,涉及28名退伍军人接受阿片类药物使用障碍 (mOUD) 药物治疗,并经历中度疼痛.
- 与对照组对抗CBM干预效应的比较.
- 评估疼痛严重程度,干扰,灾难化,阿片类药物渴望和戒断症状.
主要成果:
- CBM没有显著改变阿片类药物渴望或疼痛强度 (p ≥ .111).
- 没有发现CBM与其他结果之间有显著的关联,包括疼痛干扰,疼痛灾难化和主观阿片类药物戒断 (p ≥ .125).
结论:
- 这项试点研究没有发现证据表明,CBM对阿片类药物和疼痛线索的治疗改变了疼痛严重程度或阿片类药物渴望.
- 初步发现表明,修改注意偏差和实现临床显著结果之间存在潜在的区别.
- 需要更大,更多样化的样本和先进的方法来进一步探索CBM在成和疼痛管理中的有效性.
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