在美国成年人中,有资格接受resmetirom的人口:基于NHANES 2017-March 2020的估计分析
Hepatology communications
|June 19, 2025
概括
数以百万计的美国成年人有资格接受resmetirom,这是治疗代谢功能障碍相关的脂肪肝炎 (MASH) 的新疗法. 根据患者选择标准的严格性,资格估计有所不同.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床药理学 临床药理学
- 流行病学 流行病学
背景情况:
- Resmetirom被FDA批准用于治疗与中度至晚期肝纤维化 (F2-F3) 相关的非循环性代谢功能障碍相关的脂肪肝炎 (MASH).
- 估计有资格接受resmetirom的美国成年人群对于了解治疗可及性至关重要.
- 二次分析侧重于2型糖尿病 (T2DM) 患者的子组.
研究的目的:
- 为了估计美国成年人有资格接受resmetirom治疗的数量.
- 根据两个不同的标准 (自由和限制性) 来评估资格.
- 分析符合条件的患者的特征,包括T2DM患者.
主要方法:
- 国家健康和营养检查调查 (NHANES) 2017-2020年3月数据的横截面分析.
- 根据氨酸氨基转移酶 (ALT),受控减弱参数 (CAP) 和肝硬度测量 (LSM) 值,定义了两个符合条件的场景.
- 采样权重用于全国代表性的人口估计.
主要成果:
- 估计有830万成年人符合自由的资格标准 (ALT>17/20 U/L,CAP>280 dB/m,LSM>8 kPa).
- 据估计,有230万成年人符合限制性标准 (ALT>30 U/L,CAP>280 dB/m,LSM>10 kPa).
- 在患有T2DM的成年人中,有350万符合自由标准,有085万符合限制性标准.
结论:
- 美国有相当多的成年人口符合 resmetirom.com 的资格标准.
- 据估计,符合条件的患者数量因所适用的选择标准的严格性而有很大差异.
- 这些发现突显了resmetirom治疗在美国人口中的潜在影响力.
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