饮食组成会影响脂肪性肝病的自然史
Lauren E Callans1,2, Kerry L Ivey3,4,5, Kyong-Mi Chang1,2
1Department of Gastroenterology Section, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.
Hepatology communications
|June 19, 2025
概括
饮食习惯显著影响代谢相关脂肪性肝病 (MASLD) 的进展. 摄入蔬菜,坚果和咖啡可能会防止肝纤维化,而加工食品和精制碳水化合物可能会使其恶化.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 代谢性疾病研究研究
背景情况:
- 代谢相关的脂肪性肝病 (MASLD) 可能导致进展性肝纤维化.
- 饮食因素与调节MASLD中的纤维化进展有关.
- 了解这些饮食联系对于管理MASLD至关重要.
研究的目的:
- 确定与MASLD肝纤维化进展相关的特定饮食成分和行为.
- 在一个大规模的MASLD队列中调查饮食和肝脏相关结果之间的关系.
主要方法:
- 对大量MASLD队列 (n=84,024) 的分析,其中包括来自生活方式调查和食物频率问卷的详细饮食数据.
- 通过Fibrosis-4斜率评估肝纤维化进展,并通过ICD代码评估肝硬化时间.
- 引导弹性网回归和多变量通用线性/Cox模型用于识别饮食关联.
主要成果:
- 咖啡,茶,蔬菜,豆类,坚果,适度的酒精,白肉,米/面食,乳制品和酸盐/维生素K,咖啡因,贝他因,氨基酸和β-胡卜素等营养素的消费与纤维化进展的减少有关.
- 摄入白面包,饼干,早餐谷物,非血红素铁,B族维生素和黄素与纤维化进展的增加有关.
结论:
- 饮食模式显著影响MASLD的进展.
- 加工食品,高果糖食品和精制碳水化合物可能会加速纤维化.
- 蔬菜,坚果,全谷物和咖啡因似乎对MASLD的进展有保护作用.
关键词:
在FIB-4中,FIB-4是第一个被指控的.地中海饮食 地中海饮食贝他因 (betaine) 是一种蛋白质.咖啡因 咖啡因是一种咖啡因.肝硬化是肝硬化的一种疾病.咖啡 咖啡 咖啡 咖啡 咖啡没有补偿,没有补偿.饮食 饮食 饮食 饮食脂肪肝是一种脂肪肝.纤维化 纤维化纤维化-4-4的情况果糖是葡萄糖中的一种.与代谢相关的脂肪肝炎.与代谢相关的脂肪性肝病.更多相关视频
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