肺癌中与癌症相关的厌食症相关的生物标志物:范围审查
Xiaoying Sun1,2, Yunhao Chen3, Zhaohui Zhang4
1School of Nursing, Sun Yat-Sen University, Guangzhou, China.
概括
肺癌中的癌症相关性厌食症 (CRA) 涉及复杂的生物标志物失调. 识别这些生物标志物可以指导精确干预,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 基因组学就是基因组学.
背景情况:
- 厌食症是肺癌患者的重要并发症,影响生活质量和生存率.
- 与癌症相关的厌食症 (CRA) 导致营养不良和缓解症,需要对其生物学基础有更深入的了解.
研究的目的:
- 系统地审查和综合有关肺癌中CRA相关的生物标志物的证据.
- 为了澄清驱动CRA的生物机制,并为有针对性的治疗策略提供信息.
主要方法:
- 进行了全面的文献搜索,以确定肺癌中CRA生物标志物的研究.
- 数据提取和分析的重点是途径,基因组,转录组,表观遗传,蛋白质组,代谢和复合生物标志物.
主要成果:
- 在33项研究中,超过100个与肺癌中CRA相关的生物标志物被确定.
- 生物标志物包括炎症性细胞因子,代谢标志物,表观遗传/转录基因变异和破坏的信号通路,表明多因素失调.
- 营养和抗炎干预措施显示出调节生物标志物概况和改善结果的潜力.
结论:
- 肺癌中CRA是一种复杂的综合征,由炎症,代谢和信号通路之间的相互作用驱动.
- 多omics生物标志物集成为早期检测和个性化治疗CRA提供了潜在的潜力.
- 需要进一步的大规模研究来验证生物标志物的实用性,并优化精确干预的管理策略.
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