波萨可纳,高压氧气疗法和甲基蓝的辅助使用用于COVID-19相关的粘膜菌症
Sujata Mohanty1, Neeraj Bansal2,3, Anjali Verma1,4
1Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, Bahadur Shah Zafar Marg, New Delhi, 110002, India.
Oral and maxillofacial surgery
|June 19, 2025
概括
包括口服波萨科纳,高压氧 (HBO) 治疗和甲基蓝在内的辅助疗法有效地预防了COVID-19相关的 sino-maxillary 和 mandibular mucormycosis 的进展. 这种综合方法在2年的随访中没有显示进一步的疾病进展.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 高压医学高压医学
背景情况:
- 与COVID-19相关的粘真菌菌是一种严重的真菌感染.
- 中和下干涉是常见的表现.
- 危险因素包括高血糖,类固醇使用和铁/补充剂.
研究的目的:
- 为了评估COVID-19相关的粘膜菌的多模式治疗策略的有效性.
- 评估口服波萨可纳,高压氧疗法 (HBO) 和甲基蓝作为外科手术辅助剂的作用.
- 为了防止下和下粘膜菌病的进一步进展.
主要方法:
- 对38名患有COVID-19相关的 sino-maxillary或 mandibular mucormycosis的患者进行了回顾性观察性研究.
- 所有患者都接受了手术脱bridement.
- 辅助治疗包括口服波萨可纳,脱bridement后的HBO疗法,以及局部甲蓝应用与蒸汽吸入.
主要成果:
- 在2年的随访期间,38名患者没有观察到进一步的疾病进展.
- 32个病例 (84.21%) 涉及 sino-maxillary 区域,5个 (13.15%) 涉及下.
- 并发症包括伤口脱光 (39.47%) 和行为菌病的同时感染 (21.05%).
结论:
- 同时使用口服波萨可纳,辅助HBO治疗和甲基蓝在预防疾病进展方面是有效的.
- 这种多模式的方法为管理复杂的粘膜菌病例提供了一个有希望的策略.
- 进一步的研究可能会探索优化这种组合疗法以改善结果.
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