小儿霍奇金淋巴瘤和非霍奇金淋巴瘤的流行病学趋势:一项基于美国人口的研究
Weishi Cheng1, Xu Sun2, Shijie Yang3
1Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Annals of hematology
|June 19, 2025
概括
儿童淋巴瘤发病率在2003年后增加,患病率上升. 相比之下,成年人淋巴瘤发病率下降,死亡率在40年内显著下降,显示了儿科癌症结局的积极趋势.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 儿科霍奇金淋巴瘤 (HL) 和非霍奇金淋巴瘤 (NHL) 与成人形式不同,较少见.
- 了解儿科和成人淋巴瘤发病率,流行率和死亡率的趋势对于公共卫生战略至关重要.
研究的目的:
- 从1975年到2018年,分析和比较儿童和成人淋巴瘤的流行病学趋势.
- 评估儿童和成人淋巴瘤群体发生率,流行率和死亡率的变化.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库 (1975-2018) 的数据.
- 分析了儿童 (7,871例) 和成人 (226,211例) 淋巴瘤的年龄调整的发病率,流行率和死亡率.
- 计算年度百分比变化 (APC) 以确定特定时期的趋势.
主要成果:
- 儿童淋巴瘤发病率从1975年至2002年没有显著变化,但在2003年后增加 (APC = +1.31).
- 儿科淋巴瘤患病率上升,5年期患病率上升,20年期患病率呈现稳定的上升趋势.
- 近年来,成年淋巴瘤发病率下降,而死亡率在最初上升后,在1994年之后显著下降 (APC = -0.49).
- 儿童淋巴瘤死亡率在40年内持续下降 (APC = -3.12).
结论:
- 近年来,儿童淋巴瘤发病率呈上升趋势,伴随着患病率的上升.
- 成年淋巴瘤的趋势显示,发病率下降,死亡率显著下降,这表明结果有所改善.
- 四十年来,儿童淋巴瘤死亡率的持续下降表明,尽管发病率不断增加,治疗或护理的进展是积极的.
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