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低温的幼儿严重细菌感染的危险因素:多中心,回顾性病例对照研究的协议
Sriram Ramgopal1, Paul Aronson2,3, Douglas Lorenz4
1Division of Emergency Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.
JMIR research protocols
|June 19, 2025
概括
婴儿的低温可能是严重细菌感染 (SBI) 的信号. 这项研究旨在确定这些婴儿SBI的预测因子,以指导治疗并减少不必要的程序.
科学领域:
- 儿科急救医学 儿科急救医学
- 传染性疾病 传染性疾病
- 新生儿护理 新生儿护理
背景情况:
- 幼儿出现急诊部 (ED) 的低温是严重细菌感染 (SBI) 的潜在指标.
- 了解低温婴儿SBI的流行病学对于开发有效的诊断和管理策略至关重要.
- 改进的预测模型可以最大限度地减少婴儿不必要的侵入性手术和抗菌素暴露.
研究的目的:
- 描述SBI和简单疹病毒 (HSV) 在低温的婴儿中的流行病学.
- 在这个人群中评估SBI生物标志物的预测值.
- 推导和验证SBI在低温婴儿中的多变量预测模型.
主要方法:
- 在28个美国儿科ED (2013-2022) 进行了回顾性嵌套病例对照研究.
- 包括患有低体温 (直肠温度<36.5°C) 的婴儿,不包括患有发烧,创伤或心脏骤停的婴儿.
- 分析包括描述性统计数据,生物标志物的接收器运营商特征曲线,以及用于模型开发的惩罚性混合效应物流回归.
主要成果:
- 从16个地点对45,673名婴儿 (平均年龄25天,52.9%为男性) 的初步分析.
- 总体SBI率为0.7% (340名婴儿),其中有103例细菌病或脑膜炎.
- 在患有SBI的婴儿中,死亡率为2.1%.
结论:
- 该研究将使用基于共识的SBI结果衡量方法和病例控制方法.
- 将使用来自美国儿童医院的多中心样本.
- 这些发现旨在改善ED中低温的幼儿的管理.
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