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Updated: Sep 19, 2025

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从表型屏幕发现氧化酸化抑制剂的发现和优化

Mahmoud El Shemerly1, Florian Richalet, Dimitri Robay

  • 1Basilea Pharmaceutica International Ltd, Allschwil, Switzerland.

Anti-cancer drugs
|June 19, 2025
PubMed
概括

研究人员确定了针对癌细胞中的线粒体氧化酸化 (OXPHOS) 的新型抑制剂. 这些化合物在治疗依赖OXPHOS的癌症方面表现有前途,提供了新的治疗策略.

关键词:
电子传输链中的电子传输链.线粒体复合体I 线粒体复合体I氧化酸化是一种氧化酸化.抑制瘤生长 抑制瘤生长

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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