患有阿片类药物使用障碍的患者的深度内磁刺激:双盲,安慰剂控制的随机试验
Soner Guldas1, Selim Tumkaya2,3, Bengu Yucens2
1Department of Psychiatry, Gaziantep State Hospital, Gaziantep, Turkey.
Addiction biology
|June 19, 2025
概括
这项研究调查了针对阿片类药物使用障碍 (OUD) 的大容量跨脑磁性刺激 (TMS). 虽然耐受性很好,但与假装治疗相比,大容量TMS并没有显著减少渴望或改善相关症状.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
背景情况:
- 阿片类药物使用障碍 (OUD) 是一种慢性,复发性脑部疾病,伴随着持续的治疗挑战.
- 大脑刺激方法显示出OUD治疗的前景,但深度经磁刺激 (dTMS) 的疗效仍未得到充分探索.
- 大容量TMS是一种dTMS技术,以前没有对OUD进行过研究.
研究的目的:
- 为了评估大容量TMS的有效性,使用双圈作为OUD的附加治疗.
- 评估大量TMS对OUD患者的阿片类药物渴望,抑郁,焦虑和冲动性的影响.
主要方法:
- 一项随机,双盲,假控制的研究,涉及55名OUD患者.
- 参与者接受了活跃的宽体积TMS (10Hz,每天两次,持续2周) 或虚假的TMS,针对左侧脊侧前额皮层 (DLPFC).
- 评估包括阿片类药物渴望视觉模拟量表 (OC-VAS),汉密尔顿抑郁/焦虑评分量表 (HDRS/HARS) 和巴拉特冲动性量表-11 (BIS-11).
主要成果:
- 活跃TMS组的21名患者和假药组的19名患者完成了这项研究.
- 活跃的TMS组显示出更大的渴望减少和更少的布普伦诺芬-纳洛剂量增加的趋势,但这些并没有达到统计学意义.
- 对于渴望,抑郁,焦虑或冲动性,在活性和假的TMS之间没有观察到统计学上显著的差异.
结论:
- 应用到左侧DLPFC的大量TMS在OUD患者中耐受良好.
- 与假药相比,治疗并没有在初级或二级结果指标上产生统计学上显著的改善.
- 观察到的趋势表明大容量TMS的潜力,需要进一步研究更大的样本和优化的协议.
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