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Updated: Sep 19, 2025

Visualizing Shifts on Neuron-Glia Circuit with the Calcium Imaging Technique
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使用控制理论方法,从成像中预测神经元激发.

Nicholas A Rondoni1, Fan Lu1, Daniel B Turner-Evans2

  • 1Department of Applied Mathematics, University of California Santa Cruz, Santa Cruz, California, United States of America.

PLoS computational biology
|June 19, 2025
PubMed
概括

这项研究引入了一种新的算法,将缓慢的成像数据转换为精确的神经元发射率. 该方法使用确定性模型进行实时分析,改善我们对行为期间大脑活动的理解.

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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
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