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线粒体动力学功能障碍和神经发育障碍:从病理机制到临床翻译

Ziqi Yang^1,2, Yiran Luo¹, Zaiqi Yang¹

¹Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.

Neural regeneration research

|June 19, 2025

概括

线粒体功能障碍与神经发育障碍有关,如自闭症和雷特综合征,由于动力学和清除功能受损,导致氧化应激. 针对线粒体平衡,为这些疾病提供了统一的治疗方法.

科学领域:

神经科学是一个神经科学.
细胞生物学细胞生物学
遗传学遗传学是一个

背景情况:

线粒体功能障碍与神经发育障碍 (NDD) 有关,例如自闭症谱系障碍 (ASD),注意力缺陷/多动症障碍 (ADHD) 和雷特综合征.
这些NDD具有共同的病理特征,包括异常的线粒体动力学,受损的自清除,氧化还原失衡和神经元中的氧化应激.

研究的目的:

审查线粒体动力学功能障碍和NDD之间的关系.
在NDDs的背景下,探索线粒体质量控制机制的作用,例如神经元健康中的线粒体衰变.

主要方法:

关于线粒体动力学,线粒体和NDD的研究的文献综述.
对遗传突变,动物模型和与ASD,ADHD和Rett综合征中线粒体功能障碍相关的临床数据的分析.
检查针对线粒体通路的转化治疗策略.

主要成果:

线粒体融合裂变动态的失调导致损坏的线粒体的积累,并加剧了NDD中的氧化应激.
线粒体融合蛋白的突变与ASD有关,在雷特综合征模型中观察到线粒体菌缺陷.
临床证据表明线粒体功能受损,氧化应激,以及ASD,ADHD和Rett综合征的脆弱性增加.

结论:

线粒体平衡是NDD病理生理学的关键统一因素.
针对线粒体动力学,线粒体和生物发生的治疗干预措施对NDD有希望.
在临床环境中验证这些以线粒体为重点的策略对于推进精准医学和改善患者治疗结果至关重要.

关键词:

自闭症谱系障碍自闭症谱系障碍自死细胞清除的过程.细胞平衡是细胞的平衡.核聚变和核裂变是一种线粒体的动力学线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.神经再生的神经再生神经发育障碍神经发育障碍神经元的能量代谢.氧化应激是一种氧化应激.

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