重新评估2型糖尿病缓解的概念:呼吁以患者为中心的方法
Kamlesh Khunti1, Dimitris Papamargaritis1, Vanita R Aroda2
1Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK.
The lancet. Diabetes & endocrinology
|June 19, 2025
概括
2型糖尿病的缓解往往是暂时的,大多数患者恢复体重并经历疾病复发. 持续控制高血糖和减肥可能比缓解本身更重要.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 糖尿病管理 糖尿病管理
背景情况:
- 2型糖尿病的管理侧重于体重和心血管风险因素.
- 2型糖尿病的缓解,通常通过减肥来实现,根据2021年共识定义,通常是暂时的.
- 大多数人经历体重恢复和疾病复发后实现缓解.
研究的目的:
- 检查2型糖尿病缓解的定义和可行性.
- 评估当前的缓解模式及其与临床现实相协调.
- 突出需要更好地满足患者需求的方法.
主要方法:
- 关于2型糖尿病缓解定义和结果的当前文献的综述.
- 分析2021年关于2型糖尿病缓解的共识定义.
- 对减肥和高血糖控制的干预措施的评估.
主要成果:
- 2型糖尿病缓解通常是暂时的状态,重量恢复和复发的比例很高.
- 对一些人来说,持续缓解是可能的,改善生活质量并减少并发症风险.
- 没有确的证据表明,没有降血糖药物的缓解优于使用降血糖药物的治疗.
结论:
- 持续控制高血糖和脂肪是比缓解本身更相关的.
- 在2型糖尿病缓解定义中存在矛盾.
- 临床方法应该更好地与患者的需求和现实保持一致.
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