肺癌和心血管疾病:常见的病理生理学和治疗-新出现的毒性
Malak El-Rayes1, Inbar Nardi Agmon2, Christopher Yu2
1Department of Medicine, Division of Cardiology, Centre intégré de santé et de services sociaux de Laval, Hôpital Cité de la Santé, Laval, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, Canada.
JACC. CardioOncology
|June 19, 2025
概括
肺癌患者因共同的风险因素和癌症治疗而面临心血管疾病 (CVD) 的高发病率. 本综述涵盖肺癌中的心血管疾病,重点关注风险,预防和管理策略.
科学领域:
- 瘤学和心脏病学
- 关于癌症和心血管健康的跨学科研究.
背景情况:
- 肺癌患者在癌症患者中表现出先前存在的心血管疾病 (CVD) 的患病率最高.
- 共同的风险因素,如吸烟和社会经济地位,以及共同的生物学途径,有助于这一群体中心血管疾病的高发病率.
- 肺癌治疗,包括手术,放射治疗,化疗,免疫治疗和向治疗,独立地与心血管风险增加有关.
研究的目的:
- 提供肺癌和心血管疾病之间的相互作用的全面概述.
- 讨论肺癌患者心血管疾病的多方面的驱动因素.
- 在肺癌的背景下概述CVD风险评估,监测,预防和治疗的当前策略.
主要方法:
- 文献综述综合了关于肺癌和心血管疾病的当前知识.
- 分析共享的风险因素和生物机制,将肺癌和心血管疾病联系起来.
- 检查各种肺癌治疗方式对心血管的影响.
主要成果:
- 与其他癌症群体相比,肺癌患者在诊断后心血管事件的风险明显更高.
- 改善肺癌存活率需要更多地关注心血管疾病的管理,这会影响整体存活率和生活质量.
- 多模式癌症疗法有助于增加心血管疾病的负担.
结论:
- 心血管疾病是肺癌患者的关键问题,影响他们的整体预后和生活质量.
- 有效的管理需要综合战略来解决共同的风险因素,与治疗相关的毒性,以及主动的CVD监测和干预.
- 需要进一步的研究和临床指导方针来优化肺癌患者的心血管护理.
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