Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

2.3K
Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
2.3K
Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

4.9K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
4.9K
Adaptability of Cytoskeletal Filaments01:12

Adaptability of Cytoskeletal Filaments

3.9K
The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...
3.9K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.8K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.8K
Elastic Strain Energy for Shearing Stresses01:20

Elastic Strain Energy for Shearing Stresses

297
As discussed in previous lessons, strain energy in a material is the energy stored when it is elastically deformed, a concept crucial in materials science and mechanical engineering. This energy results from the internal work done against the cohesive forces within the material. When a material undergoes shearing stress and corresponding shearing strain, the strain energy density, which is the energy stored per unit volume, is calculated. Within the elastic limit, where the stress is...
297
Mechanical Protein Functions01:58

Mechanical Protein Functions

5.1K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
5.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Strain-localized luminescent e-skin for high-resolution pressure mapping and visual force feedback.

Nature communications·2026
Same author

Bridging the Gap - Advancing Microfluidics From Laboratory to Point-of-Care.

IEEE reviews in biomedical engineering·2026
Same author

A Portable and Dual-Button Microneedle Device Enables Intelligent Multimodal Laser Sensing.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Wash-Free Digital Detection of Tumor Extracellular Vesicles via Plasmonic Droplet Microfluidics.

ACS sensors·2026
Same author

Programmable Milli-Microfluidics via Oxide-Mediated Continuous Electrowetting of Liquid Metal Droplets.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Extended reality in clinical neurology: From interdisciplinary innovations to clinical practice.

Cell reports. Medicine·2026
Same journal

Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and Sex.

Annals of biomedical engineering·2026
Same journal

A Pressure Difference-Based Strategy for Blood Oxygen Control in Membrane Oxygenators: Reduced Modeling, Computational Simulation, and Exploratory In Vivo Evaluation.

Annals of biomedical engineering·2026
Same journal

Multidirectional Optical Bone Densitometry Using a Simulation-Based Machine Learning Model: Experimental Validation with Bone Phantoms.

Annals of biomedical engineering·2026
Same journal

Numerical Study of Human Torso Mechanical Response and Injury Assessment Under Blast Loading with Bulletproof Protection.

Annals of biomedical engineering·2026
Same journal

Immediate and Mid-Long-Term Effects of Foot Orthoses on Gait Biomechanics and Clinical Characteristics in Medial Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Annals of biomedical engineering·2026
Same journal

Screening and Evaluation of Post-stroke Dysphagia: Insights from Neurology, Artificial Intelligence and Data Science-A Scoping Review.

Annals of biomedical engineering·2026
查看所有相关文章

相关实验视频

Updated: Sep 18, 2025

Quantitative Analysis of Viscoelastic Properties of Red Blood Cells Using Optical Tweezers and Defocusing Microscopy
08:03

Quantitative Analysis of Viscoelastic Properties of Red Blood Cells Using Optical Tweezers and Defocusing Microscopy

Published on: March 25, 2022

1.5K

一个计算效率高的粘弹性真核细胞模型.

Pietro Miotti1,2, Matteo Scarpone1, Chwee Teck Lim3,4,5

  • 1Institute of Computing, Faculty of Informatics, Università della Svizzera italiana, Lugano, Switzerland.

Annals of biomedical engineering
|June 19, 2025
PubMed
概括
此摘要是机器生成的。

本研究介绍了一种计算效率高的粗粒度模型,用于模拟微流体流动中的真核细胞力学. 该模型准确地捕捉了细胞类型,使得模拟更快,参数化更简单.

关键词:
基于粗粒颗粒的方法.分散式粒子动力学是什么?细胞细胞模型模型粘弹性模型 粘弹性模型

更多相关视频

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton
08:50

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

Published on: March 10, 2023

872
Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
08:21

Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics

Published on: January 22, 2020

13.7K

相关实验视频

Last Updated: Sep 18, 2025

Quantitative Analysis of Viscoelastic Properties of Red Blood Cells Using Optical Tweezers and Defocusing Microscopy
08:03

Quantitative Analysis of Viscoelastic Properties of Red Blood Cells Using Optical Tweezers and Defocusing Microscopy

Published on: March 25, 2022

1.5K
The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton
08:50

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

Published on: March 10, 2023

872
Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
08:21

Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics

Published on: January 22, 2020

13.7K

科学领域:

  • 计算生物学是一种计算生物学.
  • 生物物理学的生物物理.
  • 细胞力学 细胞力学

背景情况:

  • 模拟真核细胞流动对于理解细胞力学和质学至关重要.
  • 由于细胞粘性弹性和变形,现有的模型往往缺乏复杂模拟所需的计算效率.

研究的目的:

  • 提出一个粗粒度模型来模拟流动中的真核细胞机制.
  • 专注于以计算效率对细胞膜,细胞核和细胞骨进行建模.

主要方法:

  • 表面三角形表示细胞和细胞核膜,捕获粘性和弹性特性.
  • 使用粘弹性键减少细胞骨复杂性,以提高计算效率.
  • 分散粒子动力学可以促进流动模拟.

主要成果:

  • 该模型使用实验数据进行校准和验证.
  • 实验包括使用MCF-10A乳腺上皮细胞进行微管吸收和微流体检测.

结论:

  • 该模型提供了简单性和准确性之间的平衡,用于模拟流动中的细胞力学.
  • 允许更快的模拟,并简化了参数化过程.
  • 对于细胞类风湿学和微流体学研究的有价值的工具.