情绪困扰和辅助生殖技术在女性中带有不明原因的不孕不育的结果:一个嵌套的病例对照研究
Jiwei Sun1,2,3,4,5,6,7, Bing Sun2, Xiaofei Sun2
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.
Archives of women's mental health
|June 19, 2025
概括
情绪上的痛苦,包括焦虑和抑郁,显著增加了女性的辅助生殖技术 (ART) 失败的风险,无法解释不育. 监测心理健康对于改善ART结果至关重要.
科学领域:
- 生殖医学 生殖医学
- 心理神经内分泌学心理学
- 不孕症研究 不孕症研究
背景情况:
- 无法解释的不孕症影响着许多女性,需要对导致因素进行研究.
- 不孕不育的情感和心理影响是一个研究不足的领域.
- 辅助生殖技术 (ART) 的结果可能受到各种患者因素的影响.
研究的目的:
- 调查情绪困扰 (焦虑和抑郁) 与ART结果之间的关联.
- 探索心理健康对ART成功率的影响,在妇女的原因不明的不育.
主要方法:
- 采用了一个嵌套的病例控制研究设计.
- 没有解释的不孕症和ART失败 (病例) 的妇女与成功的ART (对照) 的妇女根据年龄和BMI相匹配.
- 分析了1512个病例和1512个匹配的对照.
主要成果:
- 焦虑和抑郁与ART失败的风险增加有显著的关联.
- 焦虑对ART结果的影响受到怀孕前的BMI (22.796-30.914公斤/米2) 的缓解.
- 抑郁症对ART结局的影响因年龄 (27.749-39.048岁) 和怀孕前的BMI (19.514-28.389公斤/米2) 均受到缓解.
结论:
- 情绪上的困扰显著影响了无法解释的不孕症妇女的ART成功.
- 对接受生育治疗的女性来说,监测情绪上的痛苦至关重要,特别是那些患有无法解释的不孕症,正常的BMI和特定年龄段的女性.
- 这些发现强调了在不孕症护理中综合心理健康支持的重要性.
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