通过因果图形模型和高血压患者中介分析确定导致心血管死亡的途径:来自前性研究的见解
Simiao Tian1, Zhen Li2, Yanhong Bi3
1Department of Medical Records and Statistics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China. tiansimiao@dlu.edu.cn.
Journal of translational medicine
|June 19, 2025
概括
这项研究确定了高血压患者心血管死亡的直接原因,包括功能标志物和单细胞. 血尿素显著介导了估计的淋巴膜过率对心血管死亡的影响.
科学领域:
- 心血管疾病的研究研究.
- 高血压管理 高血压管理
- 生物化学标记分析分析
背景情况:
- 高血压患者的心血管 (CV) 预后涉及许多生化标志物.
- 现有的研究往往侧重于单次暴露,限制了对标记物相互作用和途径的理解.
- 确定直接的因果关系和调解效应对于改善心血管死亡率预测至关重要.
研究的目的:
- 确定生化标志物对高血压患者心血管死亡率的直接因果关系.
- 调查心血管死亡率的调解效应,以建议潜在的潜在途径.
- 建立一个因果图形模型 (CGM) 来理解复杂的心血管死亡率决定因素.
主要方法:
- 从国家健康和营养检查调查 (1999-2018) 中对3559名高血压患者进行前性分析.
- 通过国家死亡指数联系确定的心血管死亡率.
- 应用混合图形模型-快速-因果推理-最大算法 (MGM-FCI-MAX) 来构建一个CGM.
主要成果:
- 在154个月的中位数随访期间,CV死亡发生在15.79%的参与者中.
- 确定了心血管死亡的直接原因:估计的淋巴细胞过率 (eGFR),血液尿素 (BUN) 和单细胞.
- BUN显著介导30.29%的eGFR对心血管死亡率的影响;单细胞和eGFR介导性别和种族影响.
结论:
- CGM成功地确定了CV预后的直接和间接原因以及相关的介导作用.
- 研究结果强调了功能和炎症标志物在心血管死亡率中的作用.
- 洞察力可以为高血压患者的临床方案和管理策略提供信息.
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