冷血脊椎动物进化了调节性B细胞,参与炎症性疾病
Jie Wang1, Wen-Jing Dong1, Tian-Tian Tian1
1National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China.
Cell communication and signaling : CCS
|June 19, 2025
概括
鱼类中的调节性B细胞 (Bregs),称为IgM+CD25L+B细胞,产生IL-10和IL-35,抑制炎症. 这些发现揭示了从鱼类到哺乳动物对布雷格功能的进化见解.
科学领域:
- 免疫学 免疫学 免疫学
- 进化生物学 进化生物学
- 对脊椎动物进行比较研究.
背景情况:
- 调节性B细胞 (Bregs) 对于控制哺乳动物通过IL-10的炎症至关重要.
- 在鱼类等非哺乳动物脊椎动物中,Bregs的存在和功能在很大程度上仍未被探索.
- 这项研究调查了Bregs在远程实验中的差异化和功能,以了解Breg进化.
研究的目的:
- 在远鱼中识别和描述调节性B细胞 (Bregs).
- 阐明teleost Bregs.的分化机制和免疫抑制功能.
- 为了深入了解Bregs的进化起源和保护,从鱼类到哺乳动物.
主要方法:
- 使用流式细胞计,RNA-seq,qPCR和免疫光学来识别和描述teleost Bregs.
- 使用IL-35刺激和STAT3激活途径研究了布雷格分化.
- 使用细菌感染和炎症性肠病 (IBD) 模型在远鱼中评估体内功能.
主要成果:
- 在草鱼中鉴定出一种独特的IgM+CD25L+B细胞子集,具有IL-10和IL-12p35的产生.
- 证明IL-35通过STAT3诱导布雷格分化,导致IL-10的产生.
- 在体内,Teleost Bregs抑制效应性T细胞和中性粒细胞,并改善IBD.
结论:
- 鱼类拥有进化的Bregs,具有专门的抗炎功能.
- 这些发现为Bregs的遗传起源和功能性保护提供了进化见解.
- 这项研究弥合了跨脊椎动物物种的布雷格免疫学的理解.
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