感染性败血症艾滋病毒阳性患者的结果和危险因素:一项回顾性研究
Qiang Gao1,2, Tingting Wang1,3, Shun Tan3
1Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, 76# Linjiang Road, Yuzhong District, Chongqing, 400010, China.
European journal of medical research
|June 19, 2025
概括
在患有败血症的HIV阳性患者中,急性呼吸衰竭,败血性休克,慢性肝病和乳酸是关键的死亡风险因素. 使用这些因素的预测模型在预测医院死亡方面表现出很好的有效性.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 公共卫生 公共卫生
背景情况:
- 败血症对患有人类免疫缺陷病毒 (HIV) 的患者构成重大威胁.
- 了解死亡风险因素和开发预测工具对于改善这一脆弱人群的结果至关重要.
研究的目的:
- 确定与被诊断患有败血症的HIV阳性患者住院死亡相关的风险因素.
- 开发和评估一个预测模型,用于预测该患者群体的住院死亡率.
主要方法:
- 进行了一项回顾性队列研究,涉及203名住院的艾滋病毒阳性败血症患者.
- 收集和分析了基线特征,实验室发现和结果的数据.
- 患者被分为生存和死亡组,以比较风险因素.
主要成果:
- 艾滋病毒阳性败血症患者的住院死亡率为18.7%.
- 确定的独立风险因素包括急性呼吸衰竭,败血症,慢性肝病和乳酸水平升高.
- 一个随机森林 (RF) 模型显示了强大的预测性能 (AUC 0.853) 医院死亡.
结论:
- 急性呼吸衰竭,败血性休克,慢性肝病和乳酸是艾滋病毒阳性败血症患者住院死亡的重要独立风险因素.
- 开发的预测模型有效预测住院死亡率,有助于临床决策.
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