西班牙儿童Helicobacter pylori抗生素耐药性模式的演变:一项为期10年的多中心研究
Gonzalo Botija1,2, Josefa Barrio2,3, Beatriz Martínez-Escribano3
1Pediatric Gastroenterology Unit, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
Journal of pediatric gastroenterology and nutrition
|June 20, 2025
概括
在西班牙感染Helicobacter pylori的儿童中,抗生素耐药性仍然很高,尽管甲尼达耐药性已经下降. 根除率正在改善,特别是在以前没有接受过治疗的患者中.
科学领域:
- 儿童传染病 儿童传染病
- 抗微生物耐药性 抗微生物耐药性
- 胃肠病学 胃肠病学
背景情况:
- 杆菌 (H. pylori) 感染是儿童胃肠道问题的重要原因之一.
- 在H. pylori的抗生素耐药性使治疗复杂化,并影响根除成功率.
- 了解耐药性趋势对于优化儿科H. pylori治疗方案至关重要.
研究的目的:
- 在西班牙马德里,在十年内分析儿童H. pylori感染抗生素耐药性模式的趋势.
- 评估这些耐药性模式对治疗结果和根除率的影响.
主要方法:
- 进行了一项观察性,回顾性,多中心研究.
- 包括从2011年到2020年通过内镜诊断出H. pylori的儿科患者,具有积极的培养和敏感性测试.
- 对关键抗生素进行了抗菌感应性测试.
主要成果:
- 观察到高耐药率:克拉里思罗米辛 (42.9%),美特罗尼达 (24%),和利芬皮辛 (14.8%).
- 在研究期间,甲尼达抗性和双重抗性略有下降.
- 总体H. pylori根除率为76.6%,在没有先前治疗的患者中成功率显著更高.
结论:
- 马德里儿童对H. pylori的抗生素耐药性显著高,一般稳定,在降低美特罗尼达和双重耐药性方面有积极的趋势.
- 根除率的提高表明,不断发展的治疗策略正在变得更有效.
- 持续监测抗生素耐药性对于儿童群体有效的H. pylori管理至关重要.
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