长期使用100%鱼油脂注射乳液治疗儿童的必需脂肪酸缺乏症:一项纵向描述性队列研究
Kathleen M Gura1, Muralidhar H Premkumar2, Kara L Calkins3
1Department of Pharmacy, Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
JPEN. Journal of parenteral and enteral nutrition
|June 20, 2025
概括
长期服用鱼油脂质乳液治疗肠营养相关胆固醇症的儿童,患必需脂肪酸缺乏症的风险较低. 继续使用这种乳液是安全有效的,即使含有较低的林诺酸含量.
科学领域:
- 儿童营养学 儿童营养学
- 临床脂质学 临床脂质学
- 父母肠道营养是一种营养.
背景情况:
- 在2岁以下的婴儿中,亲肠道营养相关胆固醇症 (PNAC) 可能导致必需脂肪酸缺乏.
- 在PNAC中长期使用100%鱼油脂注射乳液 (FO-LIE) 是常见的.
- 评估使用FO-LIE的必需脂肪酸缺乏症 (EFAD) 的风险至关重要.
研究的目的:
- 为了评估EFAD的严重程度和风险,在长期接受100%FO-LIE的2岁以下儿童中使用PNAC.
- 在长时间内监测EFAD的生化标志物.
主要方法:
- 一个纵向描述性队列研究.
- 包括127名婴儿,每天接受1g/kg的100%FO-LIE.
- 监测三烯:四烯比率长达4年,以评估EFAD.
主要成果:
- 血清omega-3脂肪酸增加,而omega-6减少并稳定.
- 中位数的三烯:四烯比率很早就达到峰值,并保持在低水平 (0.015-0.020).
- 只有3名婴儿表现出生化EFAD,没有临床症状;所有这些都通过持续的FO-LIE解决了.
结论:
- 在患有PNAC的儿童中长期使用100%的FO-LIE与临床或生化EFAD的风险较低有关.
- 乳液是安全有效的管理EFAD风险,尽管较低的烯酸和α-烯酸含量.
- 结果支持在这个儿科群体中继续使用100%的FO-LIE.
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