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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Functions of Thyroid Hormones01:18

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Author Spotlight: Preservation of Bioenergetic Parameters in Peripheral Blood Mononuclear Cells After Cryopreservation
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在严重的甲状腺功能低下症期间,循环酸盐升高:一项观察性研究.

Yakun Li1, Mirthe H Links2, Adrian Post3

  • 1Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Metabolic syndrome and related disorders
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概括

严重的甲状腺功能低下会显著增加循环中的酸盐水平,这是线粒体功能障碍的潜在标志物. 这一发现表明,在评估酸盐时,应考虑甲状腺状况.

关键词:
循环中的酸盐分化甲状腺癌分化甲状腺癌.甲状腺功能低下症 甲状腺功能低下症体是指体中的体.线粒体功能障碍 线粒体功能障碍核磁共振光谱学 核磁共振光谱学甲状腺刺激激素激素是什么

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科学领域:

  • 生物化学 生物化学
  • 内分泌学 在内分泌学.
  • 代谢过程中的代谢.

背景情况:

  • 循环酸盐是线粒体功能障碍和死亡率的潜在生物标志物.
  • 甲状腺激素在调节新陈代谢过程中起着至关重要的作用.
  • 甲状腺功能低下,甲状腺激素不足的情况,可以导致广泛的代谢障碍.

研究的目的:

  • 为了研究严重的甲状腺功能低下对循环酸盐水平的影响.
  • 在甲状腺功能障碍的背景下,探索酸盐作为潜在的生物标志物.
  • 评估甲状腺状况和线粒体功能指标之间的关系.

主要方法:

  • 这是一项观察性研究,涉及16名差异化甲状腺癌患者.
  • 在诱导性甲状腺功能低下 (甲状腺切除术后) 和甲状腺激素补充剂后进行的测量.
  • 使用核磁共振光谱学量化的循环酸盐和体.

主要成果:

  • 在严重的甲状腺功能低下症 (平均TSH 106 mU/L) 期间,与甲状腺激素 (平均TSH 0.20 mU/L) 相比,循环中的酸盐水平高出72%.
  • 在低甲状腺症期间酸盐的增加在调整估计的膜过率和体重指数后仍然显著.
  • 在甲状腺功能低下症期间,总体没有显著变化.

结论:

  • 短期的严重甲状腺功能低下会导致循环酸盐的大量增加.
  • 这种增加可能与甲状腺功能低下症引起的线粒体功能障碍有关.
  • 在解释与健康结果相关的循环酸盐水平时,应考虑甲状腺功能状态.