小肠囊内镜在免疫介导性肠球炎:一个病例系列的四名患者
Masayuki Orikasa1, Tomoyoshi Shibuya1,2, Hirotaka Ishino1
1Department of Gastroenterology Juntendo University School of Medicine Tokyo Japan.
概括
免疫检查点抑制剂 (ICI) 可以导致免疫媒介的不良事件,如肠炎. 小肠囊内镜 (SBCE) 有助于描述这些罕见的胃肠毒性,并指导治疗决策.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 是重要的癌症免疫疗法.
- 免疫媒介不良事件 (imAEs) 是已知的ICI并发症.
- 胃肠道毒性,包括肠炎,可能会发生,小肠道的参与往往被忽视.
研究的目的:
- 通过小肠囊内镜 (SBCE) 用于免疫媒介性肠炎的细肠参与的特征.
- 评估SBCE在评估疾病程度和指导imAE肠炎治疗中的有用性.
主要方法:
- 四名患有imAE肠炎的患者的回顾性病例系列.
- 在所有病例中都进行了小肠囊内镜 (SBCE).
- 评估了对皮质类固醇和生物疗法的临床反应.
主要成果:
- SBCE揭示了小肠的各种粘膜异常,包括小性缩,口腔和侵蚀.
- 一名患者患有深层和狭窄.
- 四分之三的患者患有耐固醇性疾病,需要升级至生物疗法.
结论:
- SBCE对于诊断和评估imAE肠炎的程度非常有价值.
- SBCE的发现可以预测治疗响应度.
- 早期的SBCE可以帮助及时做出imAE肠炎的治疗决定.
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