评估阳性淋巴结的日志概率作为差异化胃癌的预后工具:一项回顾性研究
Ming-Cong Deng1,2, Ken Chen1,3,4, Qi-Mei Bao1
1Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou 310022, Zhejiang Province, China.
World journal of gastroenterology
|June 20, 2025
概括
阳性淋巴结的日志几率 (LODDS) 是胃癌生存的关键预后因素,特别是在差分化的瘤中. 这一指标在预测患者结果方面优于其他淋巴结评估.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
背景情况:
- 阳性淋巴结 (LODDS) 的日志几率与胃癌 (GC) 的存活率相关.
- 在GC中不同瘤分化水平的LODDS的预后价值尚未确定.
研究的目的:
- 在GC患者中评估LODDS的独立预后价值.
- 根据组织学差异化评估LODDS的分层预测功效.
主要方法:
- 对2103名经过激进胃切除术的GC患者进行了回顾性分析.
- 通过瘤分化分层的LODDS与其他淋巴结度量 (N阶段,阳性节点,总节点,比率) 的比较.
主要成果:
- LODDS是适度差异化到差异化GC的整体存活期的独立预后因素.
- 与其他淋巴结指标相比,LODDS显示出更高的预测准确度.
- 包括LODDS,年龄,CA 125,CEA和分化在内的名录图具有良好的预测准确性 (C指数=0.703).
- 较高的LODDS与复发/转移,晚期疾病和特定瘤特征的风险增加相关.
结论:
- LODDS作为中等差异化和差异化GC的独立预后指标.
- 对于这些患者群体,LODDS的预测性能超过了现有模型的预测性能.
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