波图拉卡 (Portulaca oleracea) L. 的水性提取物通过恢复皮肤屏障功能来缓解亚托皮炎
Haobin Wei1, Zhang Chen1,2, Wenjie Lai1,2
1School of Pharmacy, Faculty of Medicine and Laboratory of Drug Discovery from Natural Resources and Industrialization, Taipa, Macao, China.
Frontiers in pharmacology
|June 20, 2025
概括
葡萄 (PO) 水凝通过减少炎症和恢复皮肤屏障功能,有效地治疗小鼠的亚托皮炎 (AD). 它通过抑制Janus酶1 (JAK1) 和下游信号通路而起作用.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 葡萄 (Portulaca oleracea,PO) 传统上用于炎症性疾病,包括阿托皮炎 (AD).
- 精确的抗炎机制和PO的AD缓解作用尚未完全理解.
- PO含有丰富的化合物,如奥兰胺酸,具有潜在的治疗性质.
研究的目的:
- 研究PO水凝对亚托皮性皮炎 (AD) 的抗炎作用.
- 阐明PO在AD治疗作用的基础机制.
- 评估Janus激酶1 (JAK1) 抑制在PO疗效中的作用.
主要方法:
- 准备了一种PO水凝,并应用于由2,4-丁二 (DNCB) 诱导的AD的小鼠模型.
- 分子结合模拟预测aurantiamide乙酸作为一个JAK1抑制剂.
- 分析了基因和蛋白质表达,炎症标记物和JAK1/STAT信号通路激活.
主要成果:
- PO水凝显著降低了AD症状,包括皮肤病变和表皮厚度.
- PO水凝抑制了炎症因素,氧化应激和CD4+T细胞表达.
- 通过增加酶-14和菲拉格林表达,PO水凝促进了皮肤屏障的修复.
- 奥兰胺酸和PO水凝抑制了JAK1活动和下游STAT信号传输.
结论:
- 在小鼠模型中,Portulaca oleracea水凝在改善亚托皮炎方面表现出显著的有效性.
- 治疗效果归因于抑制JAK1酶活性和JAK1介导的STAT信号传递.
- PO水凝有效地恢复了表皮屏障功能,并减少了阿尔茨海默病的皮肤炎症.
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