新的COVID-19后慢性疼痛:关于危险因素和临床特征的一些信息
Fernanda de Toledo Goncalves1, Isabela Firigato1, Anne Victorio Pessotto1
1LIM40-Departamento de Medicina Legal, Bioetica, Medicina do Trabalho e Medicina Fisica e Reabilitacao da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
Pain reports
|June 20, 2025
概括
后COVID-19疼痛不同于骨关节炎疼痛,与较高的阿片类药物使用和敏感性. 片受体基因 (OPRM1) 变异与这种新的慢性疼痛状况没有显著联系.
科学领域:
- 疼痛医学 医学 疼痛医学
- 遗传学 是一个遗传学.
- 传染性疾病 传染性疾病
背景情况:
- SARS-CoV-2 感染与慢性疼痛有关,影响生活质量和功能.
- Mu-opioid受体基因 (OPRM1) 中的单核酸多态可能会影响疼痛感知和止痛反应.
- 了解遗传倾向对于COVID-19后慢性疼痛发展至关重要.
研究的目的:
- 为了比较COVID-19后 de novo疼痛的临床特征与慢性膝关节骨关节炎 (OA) 疼痛.
- 调查OPRM1基因多态 (rs1799971; rs1799972) 与COVID-19后的新生疼痛之间的关联.
主要方法:
- 评估了71名COVID-19后疼痛患者,113名膝关节OA患者和157名对照.
- 使用体检,疼痛评估,生活质量,认知和情感问卷.
- 使用TaqMan实时qPCR进行基因型化OPRM1多态化,并通过统计测试分析疼痛特征.
主要成果:
- 后COVID-19疼痛患者报告了比OA患者更高的阿片类药物摄入量,疼痛敏感性和灾难性思维.
- 膝关节OA患者表现出更清晰的疼痛描述,更高的抑郁症和认知障碍.
- 肌肉骨疾病和较低的疼痛压力值与COVID-19后的疼痛有关;OPRM1多态性没有显著的关联.
结论:
- 与其他慢性疼痛疾病相比,COVID-19后的De novo疼痛呈现出明显的临床特征.
- 量身定制的管理策略对于在后大流行时代解决COVID-19后的疼痛至关重要.
- 需要进一步研究COVID-19后疼痛的机制和遗传因素.
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