肠道微生物群的饮食指数与心脏代谢多病症之间的关联:全身免疫炎症指数和全身炎症反应指数
Sihan Hu1, Jiayuan Song2, Hui Jiang3
1School of Public Health, Guangxi Medical University, Nanning, China.
Frontiers in nutrition
|June 20, 2025
概括
较高的肠道微生物群 (DI-GM) 饮食指数得分与心脏代谢多发性疾病 (CMM) 的风险较低有关. 系统性炎症标志物部分介导这种保护作用,为CMM预防提供了洞察力.
科学领域:
- 营养科学 营养科学
- 公共卫生 公共卫生
- 微生物组研究 微生物组研究
背景情况:
- 心脏代谢多病症 (CMM) 是一个重大的全球健康挑战.
- 饮食模式影响肠道微生物群组成和全身炎症.
- 了解饮食,肠道微生物群和CMM之间的相互作用对于预防策略至关重要.
研究的目的:
- 调查肠道微生物群饮食指数 (DI-GM) 与CMM风险之间的关联.
- 检查系统免疫炎症指数 (SII) 和系统炎症反应指数 (SIRI) 在这种关系中的调解作用.
- 探索潜在的非线性关联和子组效应.
主要方法:
- 对来自NHANES (2007-2020) 的17388名参与者的横截面分析.
- 权重后勤回归和受限制的立方线模型来评估关联.
- 调解分析以量化SII和SIRI的作用.
- 对强度进行敏感性和子组分析.
主要成果:
- 更高的DI-GM得分与显著降低CMM风险相关 (OR=0.94,95%CI:0.91-0.98).
- 较高的Ln-SII和Ln-SIRI水平与较高的CMM风险显著相关 (OR=1.45,1.87分别).
- SII和SIRI部分介导了DI-GM和CMM之间的关联,分别解释了8.3%和18.1%的效应.
结论:
- 肠道微生物群的饮食指数 (DI-GM) 证明了对心脏代谢多病症 (CMM) 的保护作用.
- 如SII和SIRI所示,减少系统性炎症,部分解释了将DI-GM与降低CMM风险联系起来的机制.
- 这些发现强调了针对肠道微生物群的饮食干预措施对于CMM预防和管理的重要性.
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