狼性炎中的心血管事件:系统性审查和元分析
Mehrbod Vakhshoori1, Giv Heidari-Bateni2, Roy O Mathew3
1Division of Nephrology, Department of Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA.
Glomerular diseases
|June 20, 2025
概括
心血管事件 (CVEs) 发生在9%的狼性炎 (LN) 患者中,与系统性红斑狼 (SLE) 相比,风险更高. 早期干预对于管理LN中CVE风险至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
背景情况:
- 系统性红斑狼 (SLE) 与心血管事件 (CVEs) 有关.
- 狼性炎 (LN) 患者中CVE的发生率仍未得到充分研究.
- LN是SLE严重的表现,影响功能.
研究的目的:
- 确定狼性炎 (LN) 患者中CVE的发生率.
- 评估与SLE患者相比,LN患者的CVE风险.
- 分析LN患者中CVE发病率的地理差异.
主要方法:
- 通过PubMed,Scopus和Web of Science的数据进行了元分析.
- 纳入了在LN患者中报告CVE (心肌梗塞,心力衰竭,中风,心血管死亡) 的研究.
- 亚组分析检查了地理位置和病状况.
主要成果:
- 在LN患者中,整体CVE发病率为9% (95%CI:6-12%).
- 心肌梗塞 (MI) 和脑血管事故 (CVA) 的发病率分别为4%.
- 与SLE患者相比,LN患者的CVE风险更高 (OR:1.18,p=0.014).
- CVE发病率在地理位置上有所不同,亚洲的发病率较低 (2.3%),北美 (10.1%) 和欧洲 (13.3%) 的发病率较高.
结论:
- 心血管事件是狼性炎患者的一个重大问题.
- 狼性炎增加了心血管事件的风险.
- 早期的治疗干预对于减轻LN患者的不良结果至关重要.
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