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血清代谢和便微生物组的综合分析,用于死性肠球炎的婴儿

Zhi-Ying Lin^1,2, Shan-Shan He¹, Zi-Tong Mo¹

¹Guangzhou Key Laboratory of Neonatal Intestinal Diseases, Department of Neonatology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Frontiers in microbiology

|June 20, 2025

概括

在早产婴儿中死性肠球炎 (NEC) 与肠道细菌变化和代谢改变有关. 识别这些微生物组和代谢物转移可能有助于早期诊断NEC并了解其发展.

科学领域:

新生儿医学新生儿医学
胃肠病学胃肠病学
微生物组研究微生物组研究

背景情况:

结核性肠球炎 (NEC) 是早产婴儿的严重胃肠道疾病,对其病理学和诊断的理解有限.
多omics方法为阐明NEC病原和发现生物标志物提供了潜力.

研究的目的:

为了研究患有NEC的婴儿的肠道微生物组和血清代谢组.
通过多omics分析来识别潜在的诊断生物标志物,并了解NEC病原体.

主要方法:

在患有NEC (急性和恢复阶段) 的婴儿和对照组中,进行了便元基因组测序和血清非向代谢分析.
临床参数与多个omics数据一起分析.

主要成果:

NEC婴儿显示肠道微生物多样性减少 (较低的Chao1指数) 和细菌组成改变,包括增加大肠杆菌和减少葡萄球菌和乳杆菌物种.
在NEC婴儿中观察到代谢途径受损,特定氨基酸 (甲酸,酸,酸,酸,D-proline) 和胆酸的血清水平显著降低.
在特定的血清代谢物 (D-proline,ornithine) 和肠道细菌 (Lactobacillus paracasei,Staphylococcus epidermidis,Staphylococcus aureus) 之间发现了相关性.

结论:

NEC的特点是肠道失调,改变微生物功能和破坏宿主微生物群代谢相互作用.
血清代谢物和微生物群之间的相关性为NEC病原和潜在的诊断生物标志物提供了机械洞察力.

关键词:

代谢生物组的代谢生物组微生物组是一个微生物组.多种主题的多种主题.死性肠球炎 (necrotizing enterocolitis) 是一种致死性肠球炎的疾病.早产婴儿早产婴儿

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