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在宫病变中,基于液体细胞学的细胞块制剂的诊断实用性:比较后期分析

Ceren Canbey¹, Sena Şen², Tevhide Bilgen Özcan¹

¹Department of Medicine Pathology, Bagcilar Education and Research Hospital, University of Health Sciences, Istanbul, Türkiye.

|June 20, 2025

概括

细胞块制剂提高了诊断高度宫病变和状细胞癌的准确性,补充了巴氏涂抹和HPV测试. 在土耳其,这种方法被推用于宫癌查.

科学领域:

妇科瘤学妇科瘤学
细胞病理学细胞病理学
分子诊断学分子诊断

背景情况:

宫癌是妇女的全球健康问题,与人类乳头瘤病毒 (HPV) 感染密切相关.
传统的巴氏涂片测试和HPV测试是宫癌查的标准.

研究的目的:

评估基于液体细胞学样本的细胞块 (CB) 制剂的诊断有效性,以确定HPV阳性土耳其患者的宫病变.
评估CBs作为补充工具来测试宫癌诊断的巴氏涂抹和HPV测试.

主要方法:

通过ThinPrep Pap测试处理的60个HPV阳性宫涂抹样本的回顾性分析.
从基于液体的残留物中制备了CB,染色并进行细胞学分析.
细胞学诊断与活检的组织病理学发现进行了比较,并对相关性进行了统计分析.

主要成果:

帕普涂抹检查发现了各种等级的状上皮内皮病变,而CBs将病变分类为CIN1,CIN2,SCC或负.
组织病理活检证实了CIN1,CIN2和CIN3在患者的一个子集.
对于低度病变来说,巴氏涂片和CB之间的高度一致性;对于更高度病变来说,注意到了差异. 在HPV测试中显示高风险阳性 (HPV16,HPV18). 在HPV亚型,CB和活检结果之间发现了显著的相关性 (P <0.05).

结论:

细胞块制剂可以提高高度子宫病变和状细胞癌的诊断准确度.
CBs有效地补充了巴氏涂抹细胞学和HPV检测.
支持将CB制剂纳入土耳其的常规宫癌查方案;建议进行进一步的多中心研究.

关键词:

宫癌是发生在宫癌的原因之一.人类乳头瘤病毒人类乳头瘤病毒帕普涂抹检查是一项检查.查检查查检查查检查

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