关节软骨灵感超强而坚固的生物基聚氨纳米纤维膜
Xueqin Li1, Ningbo Cheng2, Yanyan Lin1
1State Key Laboratory of Advanced Fiber Materials, College of Textiles, Donghua University, Shanghai, 201620, China.
Angewandte Chemie (International ed. in English)
|June 20, 2025
概括
研究人员开发了生物基聚氨的生物设计,创造了强大而坚固的材料. 这种超分子网络策略提高了可持续弹性体在先进应用中的性能.
科学领域:
- 聚合物科学 聚合物科学
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
背景情况:
- 生物基聚氨提供可持续的弹性体解决方案.
- 现有的材料努力平衡机械强度和性.
- 关节软骨的结构激发了一种新的设计方法.
研究的目的:
- 创建具有增强强度和性的生物基聚氨弹性体.
- 使用刚性-灵活合的超分子交叉连接网络实施生物设计策略.
- 推进可持续的高性能聚合物.
主要方法:
- 嵌入的不对称合的刚性环和灵活的异形侧链.
- 构建了一个具有梯度键能量的动态键网络.
- 通过硬灵活合聚氨的电制造制造的纳米纤维膜.
主要成果:
- 在无形软相和晶体硬相之间实现了均的微相分离.
- 在纳米纤维膜中将微相分离结构转化为动态晶体域.
- 通过强力下的键动态证明了多层次的能量消散.
- 获得了显著增强的机械强度 (31.37 MPa),性 (102.13 MJ m−3) 和应变 (731.04%).
结论:
- 生物超分子网络设计策略成功地增强了生物基聚氨的特性.
- 这种方法产生了具有优越强度和性的高性能弹性体.
- 生物基弹性体在智能织品,柔性电子和生物医学领域的扩大应用.
相关概念视频
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.
The Extracellular Matrix
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Collagens are the Major Structural Proteins of ECM
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Connective tissue proper includes loose...
Fibronectins Connect Cells with ECM
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
Cell-matrix's Response to Mechanical Forces
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
Fibrous Proteins
Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...


