一种新的IagPLS基线校正方法用于用拉曼光谱识别质瘤
Yiran Shao1, Lipu Zhou1, Yan Zhou2
1School of Instrumentation and Optoelectronic Engineering, Precision Opto-Mechatronics Technology Key Laboratory of Education Ministry, Beihang University, Beijing 100191, China. 07935@buaa.edu.cn.
Analytical methods : advancing methods and applications
|June 20, 2025
概括
一种新的改进的自适应梯度衍生惩罚最小方程 (IagPLS) 方法增强了拉曼光谱技术,用于实时质瘤诊断. 这种技术显著提高了手术内光学活检的准确性和速度.
科学领域:
- 生物医学工程 生物医学工程
- 频谱学是一种光谱学.
- 计算生物学 计算生物学
背景情况:
- 质瘤是一种具有攻击性的中枢神经系统瘤,需要先进的诊断工具.
- 拉曼光谱提供了非侵入性的分子指纹,但受到自光干扰的影响.
- 现有的基线校正方法无法充分解决噪声,特征保存和光谱异质性问题.
研究的目的:
- 开发一种改进的基线校正方法,用于脑组织的拉曼光谱.
- 用拉曼光谱来提高手术内质瘤诊断的准确性和效率.
- 为光学活检系统提供强大的预处理工具.
主要方法:
- 提出了一种改进的自适应梯度衍生惩罚最小方程 (IagPLS) 方法.
- 集成曲率驱动的动态调整,SHAP算法引导的特征保护和量子灵感的全球优化.
- 在423个临床拉曼光谱 (157个正常,266个质瘤组织) 上验证了该方法.
主要成果:
- 通过随机森林分类,IagPLS实现了96.1%的质瘤识别准确度,表现优于airPLS (89.4%) 和agdPLS (87.0%).
- 显著改善了光谱特征峰值突出 (82.05%与agdPLS相比) 并减少了负余面积 (89.79%与airPLS相比).
- 证明了快速处理 (每次校正<0.1秒) 和增强的生物解释性.
结论:
- IagPLS是一种高级的光谱校正技术,用于通过拉曼光谱对手术内质瘤进行诊断.
- 该方法为光学活检系统提供了更好的准确性,速度和可解释性.
- 该算法框架可适应用于精准医学中的多模式生物医学光谱分析.
更多相关视频
09:17Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
Published on: September 13, 2022
2.4K
08:05Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence
Published on: June 10, 2025
675
相关概念视频
01:20Raman Spectroscopy: Overview
631
The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
631
01:26Raman Spectroscopy Instrumentation: Overview
542
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
542