青少年异常性关节炎中的生物标志物:朝着精确诊断和个性化治疗的方向?
Luciana Breda1, Saverio La Bella, Armando Di Ludovico
1Department of Pediatrics, Pediatric Rheumatology Unit, University of Chieti "G D'Annunzio", Chieti, Italy.
Current opinion in rheumatology
|June 20, 2025
概括
生物标志物对于诊断和管理青少年形性关节炎 (JIA) 是至关重要的. 像calprotectin和microRNAs这样的新标记物为患有JIA的儿童提供了改进的监测,预测和个性化治疗.
科学领域:
- 类风湿病学 类风湿病学
- 儿科医学 儿科医学
- 免疫学 免疫学 免疫学
背景情况:
- 青少年异常性关节炎 (JIA) 是儿童最常见的慢性类风湿性疾病,具有持久性关节炎症和多种不同的临床亚型.
- 及时诊断和量身定制的治疗对于优化JIA患者的长期结果至关重要.
- 最近的进展侧重于识别和验证生物标志物,以提高诊断准确度,预测疾病进展,并为治疗策略提供信息.
研究的目的:
- 审查生物标志物的作用和潜力在青少年异常性关节炎的诊断,预后和管理.
- 突出新兴生物标志物及其在提高JIA精准医学中的临床实用性.
主要方法:
- 在JIA中对生物标志物的当前文献的审查.
- 对调查calprotectin,microRNA和其他分子标记物的研究进行分析.
- 对生物标志物发现的蛋白质组和代谢组分析方法的评估.
主要成果:
- 血清和突液中的calprotectin (S100A8 / A9) 水平与JIA活性相关,可能超过CRP和ESR等传统标志物.
- 升高的calprotectin可以预测疾病爆发和亚临床炎症,有助于监测和预后.
- 新兴的生物标志物,包括microRNAs和蛋白质组/代谢组研究的候选物,显示出对亚型分化,早期诊断和个性化治疗的希望.
结论:
- 生物标志物是JIA管理中不可或缺的工具,促进治疗决策和长期患者监测.
- 预计将有一个全面的生物标志物框架来加强早期诊断,指导个性化治疗计划,并改善结果预测.
- 关联动脉炎护理的未来在于利用生物标志物来实现更有效和个性化的患者管理.
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