一例无法切除的胃癌在免疫治疗后成功通过转换手术治疗,包括治疗
Mika Ogimi, Ryuzo Deguchi1, Erika Teramura
1Department of Gastroenterology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. ryuzo.deguchi@hujita-hu.ac.jp.
The Tokai journal of experimental and clinical medicine
|June 20, 2025
概括
这项研究表明,S-1,oxaliplatin和nivolumab的联合治疗可以有效治疗晚期胃癌. 一名患有无法切除的胃癌的患者在转化手术后实现了完全的反应,并且仍然没有复发.
科学领域:
- 医学瘤学 医学瘤学
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
背景情况:
- 晚期的胃癌与肝脏,胰腺侵袭和腹膜扩散构成了重大的治疗挑战.
- 对HER2阴性,高MSI和PD-L1阳性胃癌的治疗指南正在发展.
- 组合化疗和免疫疗法越来越多地被用于无法切除的胃肠道恶性瘤.
研究的目的:
- 评估S-1,氧沙 (SOX) 和nivolumab联合治疗在患有不可切除的晚期胃癌的患者中的疗效.
- 评估在晚期胃癌中接受新辅助化疗后进行转化手术的可行性.
主要方法:
- 该患者接受了11次SOX + 尼沃卢马布联合治疗.
- 用诊断成像和内镜来监测治疗反应.
- 用D2淋巴结解剖进行 laparoscopic 远端胃切除术作为转换手术进行.
主要成果:
- 观察到瘤大小的显著减少,器官透的释放和转移的消失.
- 手术后的组织病理学证实,主要部位或淋巴结中没有剩余的瘤细胞.
- 患者在手术后的16个月内仍然活着,没有复发,完成了1年的辅助SOX治疗.
结论:
- 新辅助性SOX + 尼沃卢马布治疗可以在晚期胃癌中实现病理完整反应.
- 在成功治疗晚期胃癌后,转化手术是一种可行的选择.
- 这种方法提供了一种有希望的策略,可以改善晚期胃癌的选定患者的治疗结果.
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