抑郁症症状严重程度对美国艾滋病毒感染者队列中中风风险的影响
Jimmy Ma1, Robin M Nance1, Stephanie A Ruderman1
1Department of Medicine, School of Medicine, University of Washington, Seattle, WA.
Journal of acquired immune deficiency syndromes (1999)
|June 20, 2025
概括
抑郁症的严重程度独立地增加了艾滋病毒感染者的中风风险 (PWH). 年轻的PWH (<50岁) 经历了抑郁症对中风风险的影响更大,突出了干预的潜在目标.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 临床医学 临床医学
背景情况:
- 抑郁症是一种普遍的精神疾病,也是艾滋病毒感染者中已知的中风风险因素.
- 抑郁症状严重程度对PWH中风风险的具体影响尚不清楚.
- 了解这种关系对于有针对性的预防策略至关重要.
研究的目的:
- 调查PWH中抑郁症状严重程度和发生性中风之间的关联.
- 为了确定年龄和性别是否改变抑郁症严重程度和中风风险之间的关系.
- 确定抑郁症是PWH中风的可修改风险因素.
主要方法:
- 分析了来自五个CNICS站点的13,817名成年PWH队列 (2010-2022年).
- 考克斯模型评估了随时间变化的抑郁症状严重程度 (PHQ-9分数) 和发生的中风,并调整了临床因素.
- 评估了与年龄和性别的相互作用.
主要成果:
- 较高的抑郁症状严重程度与中风风险增加有关 (aHR为1.16,P=0.01).
- 这种联系在50岁以下的PWH中更为明显 (相互作用P=0.02).
- 对社会人口统计学,心血管,艾滋病毒和物质使用因素的调整对估计进行了最小的改变.
结论:
- 抑郁症状的严重程度是PWH中风风险的独立预测因素.
- 年轻的PWH (<50岁) 特别容易受到抑郁症增加中风的影响.
- 针对抑郁症的干预措施可能会降低中风风险,特别是在年轻的PWH中.
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