慢性鼻炎治疗后鼻腔微生物群落的转变:一项观察性研究
Sangeun Lee1, Gyungcheon Kim2, Su Mi Seong1
1Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Gyeonggi, South Korea.
The Laryngoscope
|June 20, 2025
概括
慢性鼻炎治疗改变了鼻子微生物组,增加了葡萄球菌和减少了Alloprevotella. 这些鼻子微生物组的变化与改善患者的生活质量和症状减少有关.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 鼻子微生物组在维持粘膜平衡和免疫功能方面发挥着至关重要的作用.
- 以前的研究表明,慢性鼻炎的发病与鼻子微生物组的改变之间存在联系.
研究的目的:
- 评估慢性鼻炎治疗对鼻子微生物群多样性和组成的影响.
- 分析鼻子微生物组变化与治疗后症状改善之间的关系.
主要方法:
- 从22名患有慢性鼻炎的参与者中收集了鼻子微生物组样本,这些参与者在治疗前和治疗后患有慢性鼻炎.
- 治疗方案包括鼻内皮质类固醇,口服抗胰岛素和/或口服白三烯受体抗剂.
- 用验证的问卷评估症状的改善,并进行实验室测试,如血清总IgE和血液中乙氨基酸细胞百分比.
主要成果:
- 治疗显著降低了总鼻腔症状评分 (TNSS),眼部症状评分和生活质量 (QOL) 评分 (p < 0.001).
- 虽然α多样性保持不变,但治疗后组内距离显著减少 (p < 0.05).
- 葡萄球菌的相对丰富度增加,而Alloprevotella减少 (p <0.05),其中葡萄球菌,Acinetobacter和Burkholderiaceae与QOL改善相关.
结论:
- 慢性鼻炎的治疗导致鼻子微生物组合的显著变化.
- 这些微生物组变化与临床症状改善和提高生活质量有关.
- 了解这些治疗诱导的微生物组变化可以提供对慢性鼻炎病理生理学和治疗策略的见解.
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