在不同的马类物种中,RNA病毒的多样性和进化史
Yu-Hua Qi1, Zhuang-Xin Ye1, Ke-Hui Feng1
1State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.
Journal of virology
|June 20, 2025
概括
古老的马含有多种RNA病毒和集成病毒元素 (nrEVEs),揭示了病毒和这些"活化石"之间的进化联系. 研究发现了古代丘病毒感染的证据,以及宿主对病毒序列的潜在选择.
科学领域:
- 病毒学 病毒学
- 进化生物学 进化生物学
- 基因组学就是基因组学.
背景情况:
- 马 (Xiphosura: Limulidae) 是古老的节肢动物,代表了Merostomata类的唯一幸存者.
- 大基因组测序揭示了无脊椎动物中广泛的RNA病毒多样性和内源性病毒元素 (EVE).
- 了解马病毒组为RNA病毒进化和宿主生物历史提供了洞察力.
研究的目的:
- 在四种现存的马类中研究RNA病毒和内源性RNA病毒元素 (nrEVEs).
- 探索RNA病毒和马类之间的进化关系以及它们之间的关系.
- 活着的化石 活着的化石
- . . . . . . . . . . . . . 这就是为什么.
主要方法:
- 使用下一代元基因组测序对117个数据集的选.
- 识别和新型RNA病毒和马内源性病毒元素 (hcEVE) 的遗传学分析.
- 在时间尺度上对含有hcEVE的转录进行了家族遗传学分析和转录分析.
主要成果:
- 在四种物种中发现了22种新型RNA病毒和20种马内源性病毒元素 (hcEVEs).
- 大多数hcEVEs与病毒家族Chuviridae表现出同质性,这表明现代负感RNA病毒的古代海洋chuvirus起源.
- 遗传学分析表明,在马的祖先中,至少有两个独立的古老的chuvirus集成事件.
- 转录分析揭示了亚洲马类对hcEVEs的潜在选择.
结论:
- 马拥有多样化的RNA病毒组,并拥有古老的综合病毒序列 (hcEVEs).
- 这些发现支持这样一个假设:古老的丘病毒是现代负感RNA病毒的祖先.
- 证据表明,在马基因组内,病毒元素的长期共同进化和潜在的功能整合.
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