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Updated: Jun 24, 2026

Improving the Accuracy of Flow Cytometric Assessment of Mitochondrial Membrane Potential in Hematopoietic Stem and Progenitor Cells Through the Inhibition of Efflux Pumps
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在药物治疗期间,通过AIE探针量化线粒体粘度变化.

Jinghui Qiao1, Yueyao Liu2, Zhigui Ma2

  • 1Polymer Research Institute, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, PR China. zhaoxz@scu.edu.cn.

Chemical communications (Cambridge, England)
|June 20, 2025
PubMed
概括

一个新的光探针TPE-4TPP测量了抗癌药物引起的线粒体粘度变化. 这使得科学家能够量化地将药物暴露时间与线粒体内的粘度变化联系起来.

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相关概念视频

Time Course of Drug Effect01:14

Time Course of Drug Effect

The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50 percent of...