在cN0口腔状细胞癌中的IIb级转移:多中心回顾性研究
Takuma Kugimoto1, Takumi Hasegawa2, Takashi Niiyama3
1Department of Oral and Maxillofacial Surgical Oncology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan.
概括
在口腔状细胞癌 (OSCC) 患者中,IIb级淋巴结转移是罕见的,临床N0部. 椎上部解剖 (SOHND) 通常是足够的,这表明常规IIb级解剖可能是不必要的早期OSCC.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 口腔癌研究 在口腔癌研究.
背景情况:
- 部剖析是口腔状细胞癌 (OSCC) 的标准.
- IIb级解剖带有风险,由于转移发病率低,引发了关于其必要性的辩论.
研究的目的:
- 为了确定cN0OSCC患者IIb水平转移的发病率.
- 评估IIb级解剖在OSCC管理中的临床相关性.
主要方法:
- 追溯队列研究涉及222名患有cN0OSCC.的患者.
- 在2013年至2021年期间,患者在三个中心接受了上椎部解剖 (SOHND).
- 分析的重点是IIb水平转移的发生率.
主要成果:
- 总体淋巴结转移发生在25.7%的患者中.
- 只有0.9%的患者 (2例) 发现IIb级转移.
- 这两种IIb级转移病例都涉及到晚期cT4瘤 (舌头,下牙),并导致一次性复发.
结论:
- 在临床N0OSCC中,IIb级淋巴结参与不常见.
- 对大多数OSCC患者来说,椎上部解剖 (SOHND) 似乎足够.
- 省略IIb级解剖可能是选择cN0早期OSCC患者的安全选择.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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