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Updated: Sep 18, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

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发现了一种强大,选择性和多重的HIS435突变敏感甲状腺激素受体β激动剂

Qiu Li1,2, Benqiang Yao3, Shiting Zhao1,2

  • 1China-New Zealand Joint Laboratory of Biomedicine and Health, State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China.

Journal of medicinal chemistry
|June 20, 2025
PubMed
概括

一种新型化合物,15n有效地激活甲状腺激素受体β (THR-β),即使有突变. 这种强有力的激动剂在治疗像失脂症和MASH这样的代谢障碍方面表现有前途.

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