在接受静脉内贝瓦西祖马布治疗的早产婴儿中出现出血并发症
Esra Kızıldağ Özbay1, Şenol Sabancı2, Mehmet Fatih Küçük2
1Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., Muratpaşa, Antalya, 07100, Turkey. esrakizildag.md@gmail.com.
International ophthalmology
|June 20, 2025
概括
长时间停留在NICU会增加早产婴儿因早产视网膜病变而接受静脉注射贝瓦西祖马布的出血并发症. 在新生儿重症监护室的每一个额外的一天都会增加出血事件的风险.
科学领域:
- 眼科医生 眼科 眼科
- 新生儿科学 新生儿科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 早产视网膜病变 (ROP) 是早产婴儿视力损伤的主要原因之一.
- 内贝瓦西祖马布是一种非标签治疗严重的ROP,但具有潜在的风险.
研究的目的:
- 为了确定在ROP治疗白血病后发生的出血并发症的发生率.
- 为了确定与这些出血并发症相关的风险因素,早产婴儿.
主要方法:
- 对132名早产婴儿进行了回顾性分析,这些婴儿接受了用于ROP的静脉内贝瓦西祖马布治疗.
- 出血并发症被分为孕前或宫内并发症.
- 使用后勤回归分析来确定独立的风险因素.
主要成果:
- 出血并发症发生在17.4%的婴儿中.
- 长时间的NICU停留时间是出血的重要独立风险因素 (p=0.008).
- 在NICU的每一个额外的一天,出血风险增加了5.1% (OR=1.051).
结论:
- 婴儿重症监护室停留的时间是一个关键因素,影响了在ROP治疗中静脉内贝瓦西祖马布后的出血并发症.
- 甲状腺前和玻璃体出血是常见的后果.
- 尽量减少NICU停留可能会降低这些脆弱婴儿的出血风险.
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