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来自巴西环境来源的抗菌素耐药性Pseudomonas aeruginosa分离物:一个13年的基于实验室的回顾性分析

Micaela Santana Ramos¹, João Pedro Rueda Furlan¹, Lucas David Rodrigues Dos Santos¹

¹Department of Clinical Analyses, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. Do Café, S/N, Monte Alegre, Ribeirão PretoSão Paulo, 14040-903, Brazil.

Environmental monitoring and assessment

|June 20, 2025

概括

巴西的环境Pseudomonas aeruginosa对阿兹特里奥纳姆和卡巴烯姆的耐药性越来越强. 这种机会主义的病原体.

科学领域:

环境微生物学环境微生物学
抗微生物耐药性抗微生物耐药性
公共卫生公共卫生

背景情况:

抗菌素耐药性 (AMR) 构成了全球健康的重大威胁.
机会性病原体Pseudomonas aeruginosa是一个越来越令人担忧的病原体,特别是耐卡巴胺菌株.
对抗性感染的有效治疗选择有限.

研究的目的:

从2010年到2023年,分析巴西环境Pseudomonas aeruginosa分离物的抗微生物耐药性模式.
根据年份,样本类型和环境源来调查抗性趋势.
识别耐药性机制,包括碳烯酶和MCR型基因.

主要方法:

从水,土壤,沉积物和沙沙中分离的219 P. aeruginosa分子和生物化学识别.
使用磁盘扩散和微稀释进行抗菌敏感性测试.
常规PCR检测耐药分离物中的碳烯酶和MCR型基因.

主要成果:

在水 (52%) 和土壤 (43%) 中,P. aeruginosa分离物最为普遍.
对于阿兹特里诺南 (32%) 和胆固醇素 (24%),观察到高耐药率.
观察到阿兹特雷诺姆耐药性 (2014) 和卡巴胺耐药性 (2023) 的显著增加. 没有检测到碳烯酶或MCR型基因.

结论:

巴西的环境P. aeruginosa表现出有关耐药性的模式,特别是对阿兹特里和卡巴.
缺乏常见的耐药基因表明了新的或突变性耐药机制.
研究结果强调了在各种环境中耐药细菌的传播以及人为因素的影响.

关键词:

伪omonas aeruginosa 这种类型的病毒.抗微生物耐药性抗微生物耐药性亚兹特里安娜是我的母亲.碳烯的使用方法科里斯 (Colistin) 是一种色素.环境污染环境污染

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