副腹腔下丘脑中的P2X3受体:是内脏疼痛的特定点
Xiu-Min Hu1, Yong Tang2,3, Peter Illes4,5,6
1International Joint Research Centre On Purinergic Signalling, School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Purinergic signalling
|June 20, 2025
概括
研究人员在大脑中发现了不同的神经元通路,可以单独控制内脏和体质疼痛. 准对ATP敏感的P2X3受体通道 (P2X3Rs) 或VIPR2为疼痛管理提供了新的策略.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 分子生物学分子生物学
背景情况:
- 副腹腔下丘脑 (PVH) 在疼痛处理中发挥作用.
- 了解不同类型疼痛的特定神经回路对于向治疗至关重要.
研究的目的:
- 调查ATP敏感的P2X3受体通道 (P2X3Rs) 和血管活性肠道多感应受体 (VIPR2) 在PVH中对调节内脏和体质疼痛的不同作用.
- 为了确定处理这些独特的疼痛模式所涉及的特定神经元路径.
主要方法:
- 功能依赖激光捕获微剖析测序 (fLCM-Seq) 用于分析转录形状.
- 免疫组织化学可视化受体定位.
- 使用绿色光蛋白 (GFP) 来绘制神经元投影的前进性追踪.
- 选择性淘汰受体表达,以评估功能影响.
主要成果:
- 在PVH神经元中的P2X3Rs选择性地调节内脏疼痛,投射到腹侧隔膜核 (LSV).
- 在PVH神经元中的VIPR2选择性地处理体质疼痛,将其投射到尾部不确定的区域 (ZIC).
- 抑制P2X3R增强了内脏疼痛值,而抑制VIPR2则影响了体质疼痛值.
结论:
- PVH P2X3R+和VIPR2+的神经回路是不同的,分别选择性地处理内脏和体质疼痛.
- 这些发现揭示了区分内脏和体质疼痛管理的特定治疗点.
- 这项研究为开发针对不同疼痛状况的新型集中向治疗提供了基础.
相关概念视频
01:25Analgesia and Pain Management
822
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
822
01:20Pain
637
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
637
01:43Thermosensation
31.8K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
31.8K
01:44Nociception
29.5K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
29.5K
01:22Pathophysiology of Vomiting
1.2K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
1.2K
01:22Opioid Receptors: Overview
2.0K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
2.0K