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Updated: Sep 8, 2025

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益生菌补充剂在新生儿黄治疗中的作用:系统性审查
Lisa Amelia Wijaya1, Putu Wila Widiastuti2, Ni Nyoman Metriani Nesa3
1General Practitioner, Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia.
Journal of neonatal-perinatal medicine
|June 20, 2025
概括
益生菌有望通过降低胆红素水平来减少新生儿黄,从而有可能改善光疗的结果. 需要进一步的研究来确认一致的益处和安全性.
科学领域:
- 新生儿科学 新生儿科学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 新生儿黄会影响相当一部分新生儿,造成健康风险.
- 升高的非结合性胆红素水平是新生儿黄的主要原因.
- 益生菌正在被探索为黄的光疗的辅助疗法.
研究的目的:
- 系统地审查益生菌补充剂在治疗新生儿黄方面的疗效.
- 评估益生菌对黄新生儿胆红素水平和治疗持续时间的影响.
主要方法:
- 从主要数据库 (谷歌学者,PubMed,Cochrane图书馆) 来进行随机对照试验 (RCT) 的系统审查.
- 遵循PRISMA指南的研究,使用Cochrane风险偏差工具 (RoB2)进行评估.
- 纳入标准:期/前期新生儿患有黄需要光疗,比较益生菌加光疗与光疗单独.
主要成果:
- 在14项RCT中,有9项表明使用益生菌时,血清胆红素总水平显著降低.
- 一些研究报告了间接 bilirubin,光疗持续时间和住院时间的改善.
- 四项研究没有发现胆红素水平的显著变化;没有报告任何不良影响.
结论:
- 益生菌补充似乎是一个有前途的辅助治疗新生儿黄.
- 需要进一步进行高质量的研究,以确定一致的治疗效果和评估安全性.
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