食纤维缺乏对免疫检查点阻塞有效性的一致影响,跨越不同的小鼠瘤模型
Asael Roichman1,2,3, Gabriela Reyes-Castellanos3,4,5, Ziqing Chen3,6
1Department of Chemistry, Princeton University, Princeton, New Jersey.
Cancer research
|June 20, 2025
概括
在小鼠癌症模型中,食纤维对免疫检查点阻塞 (ICB) 的有效性产生了有限且不一致的影响. 其他饮食因素,而不是纤维本身,可以解释在免疫治疗中观察到高纤维饮食的临床益处.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 免疫检查点封锁 (ICB) 是一种关键的癌症治疗方法,但它的有效性有限.
- 饮食纤维通过微生物组增强ICB的作用被建议,但之前的研究已经混了饮食变量.
- 孤立纤维对复杂饮食对ICB的影响需要澄清.
研究的目的:
- 研究食纤维数量和类型对肠道微生物组,代谢组和ICB疗效在小鼠癌症模型中的影响.
- 为了区分纤维与其他食成分在以谷物为基础的饮食与纯化的饮食中的影响.
- 评估纤维对抗PD-1疗法的影响的一致性和强度.
主要方法:
- 给小鼠食的是以谷物为基础的食或以不同水平的分离纤维 (纤维素,胰岛素) 的净化饮食.
- 分析了肠道微生物组合和代谢物水平.
- 在多种瘤模型中评估了ICB疗效 (抗PD-1).
主要成果:
- 饮食类型 (和纯化) 显著影响了肠道微生物和代谢,而不是纤维含量.
- 食纤维对ICB疗效的影响比以前报告的要弱,不一致.
- 没有任何测试模型显示出支持纤维作为ICB疗效的主要驱动因素的明确模式.
结论:
- 在小鼠模型中,食纤维似乎对ICB疗效的影响有限或不一致.
- 其他饮食因素,可能与纤维摄入量相关,可能是高纤维饮食观察到的临床益处的原因.
- 这些发现可能需要对接受免疫治疗的患者的饮食建议进行重新评估.
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