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Updated: Sep 18, 2025

Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo
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Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo

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与相互透的网络调整原蛋白非线性力学驱动了三维的适应性细胞表型

Marco A Enriquez Martinez1,2, Zhao Wang1, Yanina D Alvarez2

  • 1Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.

Science advances
|June 20, 2025
PubMed
概括

细胞适应混合原网络的非线性弹性. 增加网络硬化 (硬化的开始,σc) 刺激细胞内紧张,影响细胞迁移和增殖.

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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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