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质子抑制剂和腹膜透析相关的腹膜炎:澳大利亚纽卡斯尔的一个队列研究

Kate Richards¹, Eswari Vilayur^1,2

¹Nephrology and Transplantation Unit, John Hunter Hospital, Newcastle, New South Wales, Australia.

Internal medicine journal

|June 20, 2025

概括

质子抑制剂 (PPI) 在接受腹膜透析 (PD) 的患者中没有增加腹膜炎的风险. 这项研究发现,在当地PD队列中,PPI使用率和腹膜炎率之间没有关联.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
胃肠病学胃肠病学
药理学药理学是指药理学的学科.

背景情况:

腹膜透析 (PD) 相关的腹膜炎会导致严重的并发症,包括住院治疗,PD停止和死亡.
质子抑制剂 (PPI) 经常被处方给透析患者,尽管之前的研究表明与炎风险增加的潜在联系.

研究的目的:

在接受PD的患者中调查PPI使用与整体腹膜炎风险之间的关联.
评估PPI暴露是否影响特定患者队列中的腹膜炎发病率.

主要方法:

从2012年到2021年在一家澳大利亚中心对发生的PD患者进行了回顾性分析.
患者根据PPI暴露被分类,并采用多变量Cox比例危险建模来评估对第一次腹膜炎的时间的影响.
在暴露于PPI和未暴露组之间,每年患者炎的发病率进行了比较.

主要成果:

在219名患者中,有94人接触过PPI. 皮膜炎发生在PPI组的42.6%人群中,而未暴露组的44.8%.
使用PPI并没有显著增加到第一次腹膜炎的时间风险 (HR 0.78;P=.2).
探索性分析表明,动脉样性血管疾病和周周炎之间存在潜在的关联.

结论:

在这个队列中,没有发现PPI使用与腹膜炎风险增加有关.
需要进一步的研究来协调研究中的相互矛盾的发现,并探索PPI对膜炎风险的潜在生物体特异性影响.

关键词:

队列研究是一项队列研究.最终阶段的脏疾病.腹膜透析是指腹膜透析.腹膜炎是一种腹膜炎.质子抑制剂质子抑制剂

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