探索生物衰老和癌症之间的复杂关系在意大利未来人口队列中
Martina Morelli1, Antonietta Pepe1,2, Simona Costanzo1,3
1Research Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
Aging and disease
|June 20, 2025
概括
通过BloodAgeAcc和PhenoAgeAcc测量的生物衰老加速与癌症死亡率和住院风险有关. 这种衰老指标显示了各种各样的关联,一些癌症的风险降低了,而另一些癌症的风险增加了.
科学领域:
- 老年学是一门学科.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 癌症经常与与年龄相关的慢性疾病有关,但生物衰老作为癌症风险因素的作用尚不清楚.
- 研究生物衰老对癌症风险的影响对于了解疾病病因和预防至关重要.
研究的目的:
- 检查生物衰老加速与癌症死亡率,住院和发病率之间的关联.
- 为了澄清生物衰老措施和癌症风险之间的关系,在一个大型的前性队列.
主要方法:
- 利用了Moli-sani研究 (N=24,325) 的数据,包括两代基于血液的生物年龄估计 (BloodAge和PhenoAge).
- 通过比较生物年龄和时间年龄来计算生物衰老加速 (BloodAgeAcc,PhenoAgeAcc).
- 在22985名参与者中使用多变量Cox比例危险模型来分析与癌症死亡率和住院治疗的关联.
主要成果:
- 癌症死亡率的增加独立地与每一年的PhenoAgeAcc和BloodAgeAcc的增加有关.
- PhenoAgeAcc显示,在统计学上显著增加了癌症住院的风险.
- 生物衰老加速证明了特定癌症类型的差异性风险,包括乳腺/前列腺癌风险降低 (BloodAgeAcc) 和胰腺 (BloodAgeAcc),肺和癌风险增加 (PhenoAgeAcc).
结论:
- 生物衰老加速可能对癌症风险产生异质的影响,为某些癌症提供保护,同时增加其他癌症的风险.
- 研究结果表明,生物衰老加速是癌症结果的重要因素,需要进一步调查.
- 独立的队列研究是必要的,以证实这些发现,并探索临床影响.
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