改变静止状态桃体-小脑功能连接与强迫症患者不容忍不确定性有关:一项纵向研究
Qihui Guo1, Rongrong Zhu1, Huixia Zhou1
1State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Journal of anxiety disorders
|June 20, 2025
概括
杏仁体和小脑之间的休息状态功能连接是强迫症障碍 (OCD) 中不容忍不确定性的神经标记. 这种杏仁体-小脑连接性与不确定性不耐受性随着时间的推移的变化有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 不确定性不耐受 (IU) 是强迫症 (OCD) 病理学的关键因素.
- 杏仁体和前半岛 (AI) 被认为是IU的神经相关物.
- 在强迫症中,静止状态功能连接 (rsFC) 和IU之间的关系尚不清楚.
研究的目的:
- 在强迫症患者中研究rsFC和IU之间的关系.
- 为了识别强迫症中IU的特定神经特征.
- 在心理干预后检查rsFC和IU的纵向变化.
主要方法:
- 招募了39名强迫症患者和45名健康对照 (HC).
- 使用不确定性不耐受度量 (IUS) 测量IU.
- 分析了rsFC使用种子-到-voxel方法,检查组间的差异和IUS得分的相关性,包括干预后的纵向变化.
主要成果:
- 强迫症患者的IUS得分高于HC患者.
- 在强迫症患者中,在左桃体和左小脑后叶 (CPL) 之间,以及在左AI和左骨之间发现了显著的rsFC变化.
- 左桃体-左CPL rsFC与强迫症患者的IUS得分相关,并与IU变化显示出显著的纵向关联.
结论:
- 杏仁体-大脑细胞 rsFC 是强迫症患者IU的一个特定的神经特征.
- 这种神经模式在健康对照组中不存在.
- 杏仁体-小脑 rsFC 证明了与 IU 变化的纵向合,提供了对强迫症神经机制的见解.
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