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Updated: Sep 18, 2025

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基于pyrazole的combretastatin A-4类似物作为潜在的细胞毒剂的设计,合成和生物评估

Mai H Omar1, Soha H Emam2, Demiana S Mikhail2

  • 1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt..

Bioorganic chemistry
|June 20, 2025
PubMed
概括

基于皮拉的新化合物通过抑制氨酸聚合并诱导亡,显示出强大的抗癌活性. 化合物4a在多个癌症细胞系中表现出显著的生长抑制,使其成为有前途的治疗候选者.

关键词:
这是一种2-pyrazoline.细胞灭亡 (apoptosis) 是一种死亡的过程.在 CA-4 CA-4 中.这是CBSI的CBSI.细胞毒性活动的细胞毒性.皮拉 (Pyrazole) 是一种可怕的药物.这就是ROSOS ROS.图布林 (Tubulin) 是一种原蛋白.

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